2-hydroxyquinoline 8-monooxygenase
In today's article we are going to talk about 2-hydroxyquinoline 8-monooxygenase, a topic of great relevance today. 2-hydroxyquinoline 8-monooxygenase is a topic that has captured the attention of many people around the world and has generated an intense debate in society. Throughout this article, we will explore different aspects related to 2-hydroxyquinoline 8-monooxygenase, from its origin and evolution, to its impact on people's lives. In addition, we will analyze the different perspectives and opinions that exist around 2-hydroxyquinoline 8-monooxygenase, as well as its implications at an individual and collective level. Don't miss this complete guide on 2-hydroxyquinoline 8-monooxygenase, where you will find relevant and updated information on this fascinating topic.
| 2-hydroxyquinoline 8-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a 2-hydroxyquinoline 8-monooxygenase (EC 1.14.13.61) is an enzyme that catalyzes the chemical reaction
- quinolin-2-ol + NADH + H+ + O2 quinolin-2,8-diol + NAD+ + H2O
The 4 substrates of this enzyme are quinolin-2-ol, NADH, H+, and O2, whereas its 3 products are quinolin-2,8-diol, NAD+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating). This enzyme is also called 2-oxo-1,2-dihydroquinoline 8-monooxygenase. It employs one cofactor, iron.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1Z01, 1Z02, and 1Z03.
References
- Rosche B, Tshisuaka B, Fetzner S, Lingens F (1995). "2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86". J. Biol. Chem. 270 (30): 17836–42. doi:10.1074/jbc.270.30.17836. PMID 7629085.
