3-MeO-PCMo

In this article, we will explore in detail 3-MeO-PCMo, a fascinating topic that has captured the attention of millions of people around the world. From its impact on society to its implications on everyday life, 3-MeO-PCMo has generated intense debate and aroused great interest in various communities. Throughout these pages, we will delve into different aspects of 3-MeO-PCMo, from its origin to its evolution over time, providing an exhaustive and updated analysis of this very relevant topic. By combining data, expert opinions, and testimonials from people who have been impacted by 3-MeO-PCMo, we aim to offer a broad and balanced view that enriches our readers' understanding of this fascinating topic.

3-MeO-PCMo
Legal status
Legal status
Identifiers
  • 4-morpholine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H25NO2
Molar mass275.392 g·mol−1
3D model (JSmol)
  • COC1=CC(C2(N3CCOCC3)CCCCC2)=CC=C1
  • InChI=1S/C17H25NO2/c1-19-16-7-5-6-15(14-16)17(8-3-2-4-9-17)18-10-12-20-13-11-18/h5-7,14H,2-4,8-13H2,1H3
  • Key:BOGOEDFWPOXWQE-UHFFFAOYSA-N

3-MeO-PCMo is a dissociative anesthetic drug which is similar in structure to phencyclidine[1][2] and been sold online as a designer drug.[3][4] The inhibitory effect of 3-MeO-PCMo on the reduction in the density of the drebrin clusters by NMDAR stimulation with glutamic acid is lower than that of PCP or 3-MeO-PCP, with half maximal inhibitory concentration (IC50) values of 26.67 μM (3-MeO-PCMo), 2.02 μM (PCP) and 1.51 μM (3-MeO-PCP).[5]

See also

References

  1. ^ Ahmadi A, Khalili M, Hajikhani R, Naserbakht M (April 2011). "New morpholine analogues of phencyclidine: chemical synthesis and pain perception in rats". Pharmacology, Biochemistry, and Behavior. 98 (2): 227–33. doi:10.1016/j.pbb.2010.12.019. PMID 21215770. S2CID 24650035.
  2. ^ Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, et al. (March 2020). "4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels". Psychopharmacology. 237 (3): 757–772. doi:10.1007/s00213-019-05412-y. PMID 31828394. S2CID 209169410.
  3. ^ Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, et al. (February 2018). "Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-morpholine (3-MeO-PCMo) and analogues". Drug Testing and Analysis. 10 (2): 272–283. doi:10.1002/dta.2213. PMID 28513099.
  4. ^ "3-MeO-PCMo". New Synthetic Drugs Database. Archived from the original on 2016-07-03. Retrieved 2016-02-09.
  5. ^ Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T (September–October 2019). "Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay". Journal of Pharmacological and Toxicological Methods. 99: 106583. doi:10.1016/j.vascn.2019.106583. PMID 31082488.


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