Artemisinic aldehyde Delta11(13)-reductase

In this article, we will explore Artemisinic aldehyde Delta11(13)-reductase in detail, a topic that has attracted great interest in recent years. From its origins to its relevance today, we will immerse ourselves in an exhaustive analysis that will cover different aspects and perspectives. Artemisinic aldehyde Delta11(13)-reductase is a topic of great importance that deserves to be addressed from different points of view, so we will delve into its implications, its impact on society and its relevance in the current context. Through this article, we will seek to delve deeper into Artemisinic aldehyde Delta11(13)-reductase and provide the reader with a broad and detailed vision that allows them to understand the importance and scope of this topic.

Artemisinic aldehyde Delta11(13)-reductase
Identifiers
EC no.1.3.1.92
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Artemisinic aldehyde Delta11(13)-reductase (EC 1.3.1.92, Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(11R)-dihydroartemisinic aldehyde + NADP+ artemisinic aldehyde + NADPH + H+

This enzyme i present in Artemisia annua.

References

  1. ^ Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ (January 2005). "Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua". Planta Medica. 71 (1): 40–7. doi:10.1055/s-2005-837749. PMID 15678372.
  2. ^ Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS (August 2008). "The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua". The Journal of Biological Chemistry. 283 (31): 21501–8. doi:10.1074/jbc.M803090200. PMID 18495659.