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IUPAC name 5-(2-cyclohexylideneethyl)-5-ethyl-1,3-diazinane-2,4,6-trione | |
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Properties | |
Chemical formula | C14H20N2O3 |
Molar mass | 264.325 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references |
CHEB, also known as BRN 0250312 is a convulsant barbiturate. Its mechanism of action is not fully understood.
CHEB has uncommon action compared to other barbiturates. While other barbiturates such as Barbital are usually anticonvulsants, CHEB is a convulsant.
CHEB's convulsant action is not fully understood. There may be multiple mechanisms involved in its properties;
In rats, CHEB stimulates the release of glutamate, an excitatory neurotransmitter.
In low doses, CHEB can block the action of glycine, thus operating in a strychnine similar way.
Another study has shown that CHEB could increase the release of acetylcholine. This result was not observed with some other convulsants (S(+)-MPPB, pentylenetetrazol and Ro-5-3663), suggesting that this property is unique.
Paradoxically, CHEB is able to enhance the binding of GABA, this is a strange property, as compounds that enhance GABA binding usually have anticonvulsant action, such as Diazepam.
Convulsants | |
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GABA receptor antagonists |
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GABA synthesis inhibitors | |
Glycine receptor antagonists | |
Glutamate receptor agonists | |
Convulsant barbiturates | |
Other |