Charcot–Bouchard aneurysm

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Charcot–Bouchard aneurysm
Other namesMiliary aneurysms, Microaneurysms
SpecialtyCardiology Edit this on Wikidata
Diagnostic methodCT or MRI brain scan

Charcot–Bouchard aneurysms are aneurysms of the brain vasculature which occur in small blood vessels (less than 300 micrometre diameter). Charcot–Bouchard aneurysms are most often located in the lenticulostriate vessels of the basal ganglia and are associated with chronic hypertension.[1] Charcot–Bouchard aneurysms are a common cause of cerebral hemorrhage. Charcot–Bouchard aneurysm rupture might be linked to senile plaque formation in the Alzheimer's disease.[2]

Retinal microaneurysms are seen in conditions like diabetic retinopathy,[3]: 498  HIV related retinal microangiopathy,[3]: 467  sickle cell retinopathy,[3]: 533  idiopathic macular telangiectasia[3]: 601  etc. In diabetic retinopathy, due to breakdown in blood–retinal barrier, microaneurysms may leak plasma constituents into the retina, or it may thrombose.[3]: 498 

Signs and symptoms

Main article: Intracranial hemorrhage § Signs and symptoms

If a Charcot–Bouchard aneurysm ruptures, it will lead to an intracerebral hemorrhage, which can cause hemorrhagic stroke, typically experienced as a sudden focal paralysis or loss of sensation.[1]

Pathophysiology

Charcot–Bouchard aneurysms are aneurysms in the small penetrating blood vessels of the brain. They are associated with hypertension. The common artery involved is the lenticulostriate branch of the middle cerebral artery. Common locations of hypertensive hemorrhages include the putamen, caudate, thalamus, pons, and cerebellum. [citation needed]

As with any aneurysm, once formed they have a tendency to expand and eventually rupture, in keeping with the Law of Laplace.[4][5]

Diagnosis

Usually not detected by CT angiography.[5] Retinal microaneurysms can be diagnosed using ophthalmoscopy, fundus photography, FFA, and OCT.[6]

History

Charcot–Bouchard aneurysms are named for the French physicians Jean-Martin Charcot and Charles-Joseph Bouchard.[7][8] Bouchard discovered these aneurysms during his doctoral research under Charcot.[9]

See also

References

  1. ^ a b Fausto, Vinay Kumar; Abul K. Abbas; Nelson (2005). Robbins and Cotran Pathologic Basis of Disease (7th ed.). Philadelphia: Elsevier/Saunders. ISBN 978-0-7216-0187-8.{{cite book}}: CS1 maint: multiple names: authors list (link)
  2. ^ Fu, Hualin; Li, Jilong; Du, Peng; Jin, Weilin; Gao, Guo; Cui, Daxiang (April 2023). "Senile plaques in Alzheimer's disease arise from Aβ- and Cathepsin D-enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture". FEBS Letters. 597 (7): 1007–1040. doi:10.1002/1873-3468.14549. ISSN 0014-5793. PMID 36448495. S2CID 254095098.
  3. ^ a b c d e Salmon, John F. (2020). Kanski's clinical ophthalmology: a systematic approach (9th ed.). . ISBN 978-0-7020-7713-5. OCLC 1131846767.{{cite book}}: CS1 maint: location missing publisher (link)
  4. ^ E. Goljan, Pathology, 2nd ed. Mosby Elsevier, Rapid Review Series.
  5. ^ a b Nussbaum ES, Erickson DL. The fate of intracranial microaneurysms treated with bipolar electrocoagulation and parent vessel reinforcement. Neurosurgery. doi:10.1097/00006123-199911000-00031 . PMID 105499341999;45(5):1172-4; discussion 1174-5.
  6. ^ Dubow, Michael; Pinhas, Alexander; Shah, Nishit; Cooper, Robert F.; Gan, Alexander; Gentile, Ronald C.; Hendrix, Vernon; Sulai, Yusufu N.; Carroll, Joseph; Chui, Toco Y. P.; Walsh, Joseph B. (2014-03-01). "Classification of Human Retinal Microaneurysms Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography". Investigative Ophthalmology & Visual Science. 55 (3): 1299–1309. doi:10.1167/iovs.13-13122. ISSN 1552-5783. PMC 3943418. PMID 24425852.
  7. ^ synd/28 at Whonamedit?
  8. ^ C. J. Bouchard. Étude sur quelques points de la pathogénie des hémorrhagies cérébrales. Paris, 1867.
  9. ^ Gupta, Kashvi; M Das, Joe (2020), "Charcot Bouchard Aneurysm", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31971704, retrieved 2021-01-01