Chlormerodrin

In the following article the topic of Chlormerodrin will be addressed from different perspectives, with the aim of providing a complete and detailed view of this topic. Fundamental aspects will be analyzed, different opinions will be explored and specific cases will be presented that exemplify the importance and relevance of Chlormerodrin today. Likewise, relevant data, updated statistics will be presented and the impact that Chlormerodrin has had in various areas of society will be delved into. Through this article we aim to provide the reader with solid and up-to-date knowledge about Chlormerodrin, so that they can thoroughly understand this topic and form their own opinion about it.

Not to be confused with the herbicide Diuron.
Chlormerodrin
Names
IUPAC name
3-carbamoylamino-2-methoxypropylmercury(II) chloride
Systematic IUPAC name
3-chloro-mercura-2-methoxy propylurea
Other names
  • Chloromeridin
  • Chlormerodin
  • Chlormerodrine
  • Chlormeroprin
  • Diurone
  • Katonil
  • Mercardox
  • Mercloran
  • Mercoral
  • Merculest
  • Merilid
  • Neogidrin
  • Neohydrin
  • Oricur
  • Percapyl
  • Promeran
  • Promerane
  • 3-chloro-mercuri-2-methoxy propylurea
  • (chloro)mercury
Identifiers
3D model (JSmol)
ECHA InfoCard 100.000.483 Edit this at Wikidata
  • COC(CNC(N)=O)CCl
Properties
C5H11ClHgN2O2
Molar mass 367.20 g·mol−1
Appearance Solid
Melting point 152.5 °C (306.5 °F; 425.6 K)
11 g/L
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Renal mercury poisoning
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
Chlormerodrin
Clinical data
AHFS/Drugs.comMedical Encyclopedia
ATC code
  • none
Legal status
Legal status
  • US: Withdrawn
Identifiers
  • 3-carbamoylamino-2-methoxypropylmercury(II) chloride
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
ECHA InfoCard100.000.483 Edit this at Wikidata
Chemical and physical data
FormulaC5H11ClHgN2O2
Molar mass367.20 g·mol−1
3D model (JSmol)
  • COC(CNC(=O)N)CCl
  • InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1
  • Key:BJFGVYCULWBXKF-UHFFFAOYSA-M

Chlormerodrin is a mercurial diuretic commercially traded from 1952[1] until 1974[2] that was once used to treat patients with heart failure,[3] but is no longer in widespread use.[4] The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain[5][6] and the 197Hg form was even considered a contender for 99mTc by some physicians,[7] but was ultimately discontinued by the FDA in 1989.[8]

References

  1. ^ Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia. Westwood: Noyes Publications.
  2. ^ Crout JR (1974). "Fixed combination prescription drugs: FDA policy". Journal of Clinical Pharmacology. 14 (5–6): 249–254. doi:10.1002/j.1552-4604.1974.tb02309.x. PMID 4829517. S2CID 5830209.
  3. ^ Leff WA, Nussbaum HE (April 1959). "Chlormerodrin: clinical effectiveness and absence of toxicity in congestive heart failure; report of a four-year study". British Medical Journal. 1 (5126): 883–889. doi:10.1136/bmj.1.5126.883. PMC 1992943. PMID 13629153.
  4. ^ "Chlormerodrin". PubChem. U.S. National Library of Medicine. Retrieved 2021-09-23.
  5. ^ Sodee DB, Di Stefano B (September 1965). "The Clinical Value of Today's Radioisotope Scanning". The Ohio State Medical Journal. 61: 819–22. PMID 14340215.
  6. ^ Yamamoto YL, Feindel W, Zanelli J (September 1964). "Comparative study of radioactive chlormerodrin (Neohydrin) tagged with mercury 197 and mercury 203 for brain scanning". Neurology. 14 (9): 815–820. doi:10.1212/wnl.14.9.815. PMID 14215595. S2CID 43526449.
  7. ^ Sodee DB (December 1968). "Comparison of 99mTc-pertechnetate and 197Hg-chlormerodrin for brain scanning". Journal of Nuclear Medicine. 9 (12): 645. PMID 5729215.
  8. ^ FDA, Approved Drug Products with Therapeutic Equivalence Evaluations, US Department Of Health And Human Service, 1989.


Stub icon

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.