Fispemifene

This article addresses the topic of Fispemifene from a comprehensive and detailed approach, with the aim of providing a complete and updated vision of this topic of interest. Along these lines, different aspects related to Fispemifene will be explored, from its origin and history to its impact on current society. Relevant data, recent studies and in-depth analyzes will be presented that will allow the reader to understand the importance and relevance of Fispemifene today. Likewise, reflections and perspectives will be offered to enrich the understanding of this topic and promote an enriching debate.

Fispemifene
Clinical data
Other namesHM-101
Identifiers
  • 2-(2-(4-((1Z)-4-Chloro-1,2-diphenylbut-1-enyl)phenoxy)ethoxy)ethanol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H27ClO3
Molar mass422.95 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)OCCOCCO)/CCCl
  • InChI=1S/C26H27ClO3/c27-16-15-25(21-7-3-1-4-8-21)26(22-9-5-2-6-10-22)23-11-13-24(14-12-23)30-20-19-29-18-17-28/h1-14,28H,15-20H2/b26-25-
  • Key:NKZTZAQIKKGTDB-QPLCGJKRSA-N

Fispemifene (INN, USAN) (developmental code name HM-101) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed for the treatment of male hypogonadism but was abandoned and never marketed.[1][2][3] It reached phase II clinical trials for this indication before development was terminated in March 2016.[1] The drug failed to achieve statistical significance on key effectiveness endpoints in clinical trials and was discontinued by its developer for strategic reasons.[1]

See also

References

  1. ^ a b c "Fispemifene". AdisInsight. Springer Nature Switzerland AG.
  2. ^ Cano A, Calaf i Alsina J, Duenas-Diez JL (22 September 2006). Selective Estrogen Receptor Modulators: A New Brand of Multitarget Drugs. Springer Science & Business Media. pp. 52–. ISBN 978-3-540-34742-2.
  3. ^ Ottow E, Weinmann H (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 90–. ISBN 978-3-527-62330-3.


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