IFNA14

In today's article we are going to delve into the fascinating world of IFNA14. This topic has been the subject of study and interest for years, and it is no wonder. IFNA14 has captured the attention of scientists, researchers, hobbyists and the curious alike. Throughout history, IFNA14 has played a crucial role in different aspects of everyday life, culture, technology, and society in general. In this article, we will explore the different aspects of IFNA14, from its origin to its impact on the world today. We are sure that at the end of this reading, you will have a broader and richer understanding of IFNA14. Get ready to embark on a journey of discovery and learning!

Protein-coding gene in the species Homo sapiens

IFNA14
Identifiers
Aliases	IFNA14, IFN-alphaH, LEIF2H, interferon alpha 14
External IDs	OMIM: 147579; MGI: 2667155; HomoloGene: 122139; GeneCards: IFNA14; OMA:IFNA14 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,239,002 bp[1] End 21,240,005 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 42.02 cM Start 88,561,878 bp[2] End 88,562,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal cortex muscle of leg kidney gastrocnemius muscle multicellular organism Top expressed in embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3448 230396 Ensembl ENSG00000228083 ENSMUSG00000063376 UniProt P01570 Q80SU4 RefSeq (mRNA) NM_002172 NM_177347 RefSeq (protein) NP_002163 NP_796321 Location (UCSC) Chr 9: 21.24 – 21.24 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000228083 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. ^ "Entrez Gene: IFNA14 interferon, alpha 14".

Further reading

• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi:10.1016/S0021-9258(18)42719-6. PMID 1371992.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
• Lawn RM, Adelman J, Dull TJ, et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes". Science. 212 (4499): 1159–62. Bibcode:1981Sci...212.1159L. doi:10.1126/science.6165082. PMID 6165082.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID 8910771.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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