Inosine triphosphate

In today's article we are going to talk about Inosine triphosphate, a topic that has generated great interest in recent years. Since its emergence, Inosine triphosphate has captured the attention of experts and fans alike, and has proven to have a significant impact on different aspects of society. Throughout this article, we will explore the different facets of Inosine triphosphate, from its history and evolution to its influence on the world today. Additionally, we will examine the different perspectives and opinions related to Inosine triphosphate, with the aim of offering a complete and diverse view of this topic. Without a doubt, Inosine triphosphate is a topic that leaves no one indifferent and that continues to generate debate and reflection in different areas. Join us on this journey of discovery and exploration of Inosine triphosphate!

Inosine triphosphate
2D Molecular Structure of Inosine Triphosphate
Names
IUPAC name
Inosine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name
O1-{methyl} tetrahydrogen triphosphate
Other names
iniosine triphosphate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.004.589 Edit this at Wikidata
EC Number
  • 205-046-7
KEGG
UNII
  • Key: HAEJPQIATWHALX-KQYNXXCUSA-N
  • C1=NC(=O)C2=C(N1)N(C=N2)3(((O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
Properties
C10H15N4O14P3
Molar mass 508.165 g·mol−1
903.5 mg/mL
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway, seen in the synthesis of ATP and GTP. It comprises an inosine nucleotide containing three phosphate groups esterified to the sugar moiety.

ITP results from deamination of ATP. Incorporation of ITP into the DNA from the nucleotide pool can lead to DNA damage, mutagenesis and other harmful effects.[1] ITP is processed by the enzyme inosine triphosphate pyrophosphatase (ITPA), which turns it into inosine monophosphate (IMP), to avoid incorporation into DNA.[1]

References

  1. ^ a b Ji D, Stepchenkova EI, Cui J, Menezes MR, Pavlov YI, Kool ET (November 2017). "Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera". Nucleic Acids Research. 45 (20): 11515–11524. doi:10.1093/nar/gkx774. PMC 5714213. PMID 29036687.