KRT33B

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Protein-coding gene in the species Homo sapiens

KRT33B
Identifiers
Aliases	KRT33B, HA3II, Ha-3II, K33B, KRTHA3A, KRTHA3B, hHa3-II, keratin 33B
External IDs	OMIM: 602762; MGI: 1919138; HomoloGene: 136754; GeneCards: KRT33B; OMA:KRT33B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,363,498 bp[1] End 41,369,813 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 99,902,021 bp[2] End 99,907,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex anterior cingulate cortex skin of abdomen skin of leg Brodmann area 9 right lung mucosa of esophagus right frontal lobe vagina hippocampus proper Top expressed in lip hair follicle skin of back dermis skin of external ear skin of abdomen sexually immature organism medial head of gastrocnemius muscle conjunctival fornix diencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity Cellular component extracellular exosome intermediate filament extracellular space cytosol Biological process hair cycle ageing keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3884 71888 Ensembl ENSG00000263012 ENSG00000131738 ENSMUSG00000035592 UniProt Q14525 Q8K0Y2 RefSeq (mRNA) NM_002279 NM_027983 RefSeq (protein) NP_002270 NP_082259 Location (UCSC) Chr 17: 41.36 – 41.37 Mb Chr 11: 99.9 – 99.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.^[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II hair keratin to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A and KRT33B (this gene).^[7]

References

1. ^ ^{a b c} ENSG00000131738 GRCh38: Ensembl release 89: ENSG00000263012, ENSG00000131738 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.
6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
7. ^ ^{a b} "Entrez Gene: KRT33B keratin 33B".

Further reading

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S – 59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
• Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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