Methylenetetrahydrofolate dehydrogenase (NAD+)

Today we are going to delve into the world of Methylenetetrahydrofolate dehydrogenase (NAD+), a topic that has been the subject of interest and debate in different areas over time. Methylenetetrahydrofolate dehydrogenase (NAD+) has aroused the curiosity and fascination of many people due to its importance in today's society. Throughout history, Methylenetetrahydrofolate dehydrogenase (NAD+) has played a fundamental role in different contexts, from politics and culture to science and technology. Throughout this article, we will explore the importance of Methylenetetrahydrofolate dehydrogenase (NAD+), as well as its impact on society at large. Additionally, we will look at how Methylenetetrahydrofolate dehydrogenase (NAD+) has evolved over time and how it has influenced our lives in ways we may not have considered before. Get ready to enter the fascinating world of Methylenetetrahydrofolate dehydrogenase (NAD+)!

methylenetetrahydrofolate dehydrogenase (NAD+)
Identifiers
EC no.1.5.1.15
CAS no.82062-90-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a methylenetetrahydrofolate dehydrogenase (NAD+) (EC 1.5.1.15) is an enzyme that catalyzes a chemical reaction.[1]

5,10-methylenetetrahydrofolate + NAD+ 5,10-methenyltetrahydrofolate + NADH + H+

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NAD+, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase. This enzyme is also called methylenetetrahydrofolate dehydrogenase (NAD+). This enzyme participates in one carbon pool by folate.[2]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1EDZ and 1EE9.[3]

References

  1. ^ "1.5.1.15: methylenetetrahydrofolate dehydrogenase (NAD+) - BRENDA Enzyme Database". www.brenda-enzymes.org. Retrieved 2023-02-18.
  2. ^ "Methylenetetrahydrofolate dehydrogenase NAD". LOINC. Retrieved 2023-02-18.
  3. ^ Bank, RCSB Protein Data. "RCSB PDB - 1CKM: STRUCTURE OF TWO DIFFERENT CONFORMATIONS OF MRNA CAPPING ENZYME IN COMPLEX WITH GTP". www.rcsb.org. Retrieved 2023-02-18.


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