Methylglyoxal reductase (NADH-dependent)
In the article that we present below, we want to delve into the fascinating world of Methylglyoxal reductase (NADH-dependent). Along these lines, we will explore its origins, its evolution over time and its importance in today's society. Methylglyoxal reductase (NADH-dependent) has been the subject of debate and study by experts from various disciplines, who have provided valuable knowledge that allows us to better understand its influence on our lives. Through this article, we invite you to reflect on Methylglyoxal reductase (NADH-dependent) and discover aspects that you may not have known about this topic.
| methylglyoxal reductase (NADH-dependent) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.78 | ||||||||
| CAS no. | 37250-16-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a methylglyoxal reductase (NADH-dependent) (EC 1.1.1.78) is an enzyme that catalyzes the chemical reaction
- (R)-lactaldehyde + NAD+ methylglyoxal + NADH + H+
Thus, the two substrates of this enzyme are (R)-lactaldehyde and NAD+, whereas its 3 products are methylglyoxal, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include methylglyoxal reductase, and D-lactaldehyde dehydrogenase. This enzyme participates in pyruvate metabolism.
References
- Ting SM, Miller ON, Sellinger OZ (1965). "The Metabolism of lactaldehyde: VII. The oxidation of d-lactaldehyde in rat liver". Biochim. Biophys. Acta. 97: 407–15. doi:10.1016/0304-4165(65)90151-0. PMID 14323585.
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