NBUMP

In today's world, NBUMP is a topic that has sparked a lot of interest and debate. From its origins to its evolution today, NBUMP has had a significant impact on various areas of society. Its influence has extended to aspects such as economics, politics, culture and technology, generating both admiration and controversy. In this article, we will explore in depth the various aspects related to NBUMP, analyzing its impact in different contexts and examining the implications it has today.

NBUMP
Clinical data
ATC code
  • none
Identifiers
  • N-butyl]adamantane-1-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H39N3O2
Molar mass425.617 g·mol−1
3D model (JSmol)
  • COc1ccccc1N2CCN(CC2)CCCCNC(=O)C34CC5CC(C3)CC(C5)C4
  • InChI=1S/C26H39N3O2/c1-31-24-7-3-2-6-23(24)29-12-10-28(11-13-29)9-5-4-8-27-25(30)26-17-20-14-21(18-26)16-22(15-20)19-26/h2-3,6-7,20-22H,4-5,8-19H2,1H3,(H,27,30)
  • Key:PRZPXKIXNNNNCD-UHFFFAOYSA-N
  (verify)

NBUMP is a highly selective 5-HT1A receptor partial agonist (Ki = 0.1 nM; IA = 40%) with an arylpiperazine structure.[1] It is one of the highest affinity ligands for the 5-HT1A receptor known.[1] It displays 460- and 260-fold selectivity for 5-HT1A over the α1-adrenergic and D2 receptors, respectively.[1]

See also

References

  1. ^ a b c Glennon RA (2006). "Strategies for the development of selective serotonergic agents". In Roth BL (ed.). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors). Totowa, NJ: Humana Press. p. 113. ISBN 1-58829-568-0.