In today's world, Permease of phosphotransferase system is a topic that has captured everyone's attention, whether due to its historical relevance, its impact on modern society or its influence on the development of technology. For centuries, Permease of phosphotransferase system has been the subject of study, debate and controversy, and its importance continues to increase. In this article, we will explore the various facets of Permease of phosphotransferase system, from its origins to its influence today, considering its impact on different areas of daily life. We will also examine the opinions and perspectives of experts in the field, with the goal of offering a broad and comprehensive overview of this fascinating topic.
| Phosphotransferase permease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | PTS | ||||||||
| Pfam | PF03611 | ||||||||
| InterPro | IPR004703 | ||||||||
| TCDB | 4.A.7 | ||||||||
| OPM superfamily | 426 | ||||||||
| OPM protein | 5zov | ||||||||
| |||||||||
Permease of phosphotransferase system (or PTS-AG superfamily according to TCDB) is a superfamily of phosphotransferase enzymes that facilitate the transport of L-ascorbate (A) and galactitol (G). Classification has been established through phylogenic analysis and bioinformatics.[1][2]
The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC).[3][4] The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies.
The four families that make up the PTS-GFL superfamily include: