Vaniprevir

In the modern world, Vaniprevir has become increasingly relevant in contemporary society. Whether due to its impact on culture, technological development, politics or any other field, Vaniprevir has become a topic of widespread interest and debate today. From its origins to its influence on people's daily lives, Vaniprevir has been the subject of academic studies, critical analysis and even controversies. In this article, we will explore different aspects related to Vaniprevir, analyzing its importance and scope in different contexts.

Vaniprevir
Identifiers
  • (1R,21S,24S)-21-tert-butyl-N--16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracycloheptacosa-6(11),7,9-triene-24-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.207.830 Edit this at Wikidata
Chemical and physical data
FormulaC38H55N5O9S
Molar mass757.94 g·mol−1
3D model (JSmol)
  • CC1C1(C(=O)NS(=O)(=O)C2CC2)NC(=O)3C4CN3C(=O)(NC(=O)OCC(CCCCC5=C6CN(CC6=CC=C5)C(=O)O4)(C)C)C(C)(C)C
  • InChI=InChI=1S/C38H55N5O9S/c1-7-25-18-38(25,33(46)41-53(49,50)27-14-15-27)40-31(44)29-17-26-20-43(29)32(45)30(36(2,3)4)39-34(47)51-22-37(5,6)16-9-8-11-23-12-10-13-24-19-42(21-28(23)24)35(48)52-26/h10,12-13,25-27,29-30H,7-9,11,14-22H2,1-6H3,(H,39,47)(H,40,44)(H,41,46)/t25-,26-,29+,30-,38-/m1/s1
  • Key:KUQWGLQLLVFLSM-ONAXAZCASA-N

Vaniprevir (MK-7009) is a macrocyclic hepatitis C virus (HCV) NS3/4A protease inhibitor, developed by Merck & Co., which is currently in clinical testing.[1] In Japan, it was approved for treating hepatitis C in 2014 under the brand name Vanihep.[2][3]

References

  1. ^ McCauley JA, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, et al. (March 2010). "Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor". J. Med. Chem. 53 (6): 2443–63. doi:10.1021/jm9015526. PMID 20163176.
  2. ^ "First recommendation for HCV drug vaniprevir, in Japan". datamonitorhealthcare.com. September 25, 2014.
  3. ^ "New Drugs Approved" (PDF). Pharmaceuticals and Medical Devices Agency. Archived from the original (PDF) on 2015-05-13. Retrieved 2015-08-22.
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