40S ribosomal protein S15a

In today's article we are going to delve into the fascinating world of 40S ribosomal protein S15a. We will explore its origins, its evolution over time, its impact on current society and its possible future implications. From its inception to its current state, 40S ribosomal protein S15a has played a crucial role in various aspects of human life, and it is important to understand its importance to better understand the world around us. Throughout this article, we will examine 40S ribosomal protein S15a from different perspectives and offer a detailed analysis of its influence in today's world. Get ready to embark on a journey of discovery and learning about 40S ribosomal protein S15a!

Protein-coding gene in the species Homo sapiens

RPS15A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS15A, S15a, ribosomal protein S15a, DBA20
External IDs	OMIM: 603674; MGI: 2389091; HomoloGene: 128982; GeneCards: RPS15A; OMA:RPS15A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.3 Start 18,781,295 bp[1] End 18,790,383 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 117,703,595 bp[2] End 117,715,411 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon left ovary right ovary granulocyte ventricular zone canal of the cervix skin of abdomen ectocervix body of uterus Top expressed in ventricular zone esophagus embryo genital tubercle embryo lip yolk sac morula tail of embryo blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component cytoplasm cytosol ribosome membrane extracellular exosome mitochondrion nucleoplasm extracellular matrix cytosolic small ribosomal subunit Biological process viral transcription response to virus SRP-dependent cotranslational protein targeting to membrane positive regulation of cell cycle positive regulation of cell population proliferation translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6210 267019 Ensembl ENSG00000134419 ENSMUSG00000008683 UniProt P62244 P62245 RefSeq (mRNA) NM_001030009 NM_001019 NM_170669 RefSeq (protein) NP_001010 NP_001025180 NP_733769 Location (UCSC) Chr 16: 18.78 – 18.79 Mb Chr 7: 117.7 – 117.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S15a is a protein that in humans is encoded by the RPS15A gene.^[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000134419 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000008683 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
6. ^ ^{a b} "Entrez Gene: RPS15A ribosomal protein S15a".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Chan YL, Olvera J, Paz V, Wool IG (1994). "The primary structure of rat ribosomal protein S15a". Biochem. Biophys. Res. Commun. 200 (3): 1498–504. doi:10.1006/bbrc.1994.1620. PMID 8185605.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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