FCGR2A

In this article we are going to address the issue of FCGR2A, which has been the subject of debate and analysis in various areas. FCGR2A is a topic that arouses great interest and has generated different positions among experts and the general public. Throughout this article, we will thoroughly explore the relevant aspects related to FCGR2A, as well as the implications it has in various contexts. We will focus on analyzing different approaches, recent research and perspectives that will help to more fully understand the importance and relevance of FCGR2A today.

Mammalian protein found in Homo sapiens

FCGR2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6
Identifiers
Aliases	FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDs	OMIM: 146790; MGI: 95500; HomoloGene: 47936; GeneCards: FCGR2A; OMA:FCGR2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,505,430 bp[1] End 161,524,013 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 78.8 cM Start 170,878,743 bp[2] End 170,892,504 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte placenta appendix right lung metanephric glomerulus spleen upper lobe of left lung gallbladder Top expressed in granulocyte stroma of bone marrow spermatocyte blood calvaria umbilical cord seminiferous tubule dermis right lung lobe tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding IgG binding Cellular component integral component of membrane plasma membrane membrane secretory granule membrane cell wall Biological process Fc-gamma receptor signaling pathway involved in phagocytosis immune system process neutrophil degranulation cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2212 14131 Ensembl ENSG00000143226 ENSMUSG00000059498 UniProt P12318 P08508 RefSeq (mRNA) NM_001136219 NM_021642 NM_001375296 NM_001375297 NM_010188 NM_001356511 RefSeq (protein) NP_001129691 NP_067674 NP_001362225 NP_001362226 n/a Location (UCSC) Chr 1: 161.51 – 161.52 Mb Chr 1: 170.88 – 170.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.^[5][6]

Interactions

FCGR2A has been shown to interact with PIK3R1^[7][8] and Syk.^[8][9]

See also

• CD32

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000143226 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000059498 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
6. ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
7. ^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
8. ^ ^{a b} Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
9. ^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Further reading

• McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID 11913983.
• Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J. Biol. Chem. 267 (22): 15692–700. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
• Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor". Immunogenetics. 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077. S2CID 23208039.
• Hessian PA, Highton J, Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. PMC 1541930. PMID 2527651.
• Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
• Lanier LL, Cwirla S, Yu G, et al. (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science. 246 (4937): 1611–3. Bibcode:1989Sci...246.1611L. doi:10.1126/science.2531919. PMID 2531919.
• Stuart SG, Trounstine ML, Vaux DJ, et al. (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. doi:10.1084/jem.166.6.1668. PMC 2188792. PMID 2824655.
• Hibbs ML, Bonadonna L, Scott BM, et al. (1988). "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. Bibcode:1988PNAS...85.2240H. doi:10.1073/pnas.85.7.2240. PMC 279966. PMID 2965389.
• Huizinga TW, van der Schoot CE, Jost C, et al. (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature. 333 (6174): 667–9. Bibcode:1988Natur.333..667H. doi:10.1038/333667a0. PMID 2967437. S2CID 4342856.
• Sammartino L, Webber LM, Hogarth PM, et al. (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics. 28 (5): 380–1. doi:10.1007/BF00364238. PMID 2971615. S2CID 35705081.
• Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. doi:10.1002/j.1460-2075.1988.tb02913.x. PMC 454434. PMID 3402431.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. PMID 8631888.
• Salmon JE, Millard S, Schachter LA, et al. (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. doi:10.1172/JCI118552. PMC 507190. PMID 8636449.
• Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi:10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631.
• Sármay G, Koncz G, Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. doi:10.1074/jbc.271.48.30499. hdl:2437/195888. PMID 8940017.
• Ibarrola I, Vossebeld PJ, Homburg CH, et al. (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi:10.1182/blood.V91.6.2108. PMID 9490697.

External links

• FCGR2A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

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