GUCY1A2

Nowadays, GUCY1A2 is a topic that has gained great relevance in society. Over time, GUCY1A2 has become a point of interest for a wide range of people, whether due to its impact on daily life, its historical relevance or its influence on various aspects of culture. In this article, we will explore different perspectives on GUCY1A2, from its origins to its role in the present, analyzing its importance and implications in today's society. Additionally, we will examine how GUCY1A2 has evolved over time and how its understanding can contribute to the understanding of various aspects of our daily lives.

Protein-coding gene in the species Homo sapiens

GUCY1A2
Identifiers
Aliases	GUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDs	OMIM: 601244; MGI: 2660877; HomoloGene: 47953; GeneCards: GUCY1A2; OMA:GUCY1A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 106,674,019 bp[1] End 107,018,476 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 3,532,778 bp[2] End 3,894,736 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 lateral nuclear group of thalamus visceral pleura saphenous vein postcentral gyrus tail of epididymis lower lobe of lung external globus pallidus vena cava endothelial cell Top expressed in tail of embryo genital tubercle primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus ventricular zone embryo cerebellar cortex spermatid yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP binding heme binding nucleotide binding phosphorus-oxygen lyase activity lyase activity protein binding guanylate cyclase activity adenylate cyclase activity Cellular component plasma membrane guanylate cyclase complex, soluble cytoplasm Biological process signal transduction intracellular signal transduction cyclic nucleotide biosynthetic process cGMP biosynthetic process positive regulation of nitric oxide mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2977 234889 Ensembl ENSG00000152402 ENSMUSG00000041624 UniProt P33402 n/a RefSeq (mRNA) NM_001256424 NM_000855 NM_001033322 RefSeq (protein) NP_000846 NP_001243353 n/a Location (UCSC) Chr 11: 106.67 – 107.02 Mb Chr 9: 3.53 – 3.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000152402 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000041624 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. S2CID 84974514.
6. ^ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Further reading

• Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474. S2CID 45536193.
• Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. Bibcode:2002PNAS...99..507B. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
• Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jcem.86.2.7409. PMID 11158065.
• Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
• Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
• Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.

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