PRKCG

PRKCG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E73, 2UZP
Identifiers
Aliases	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma, PKCI(3), PKCgamma
External IDs	OMIM: 176980; MGI: 97597; HomoloGene: 20602; GeneCards: PRKCG; OMA:PRKCG - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	53,907,652 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,379,615 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; nucleus accumbens; ; prefrontal cortex; ; Amygdala; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; caudate nucleus; ; right hemisphere of cerebellum; ; hippocampus proper;
	Top expressed in
	hippocampus proper; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; Cerebellum; ; cerebellar cortex; ; Cortex of frontal lobe; ; superior frontal gyrus; ; striatum of neuraxis; ; Hypothalamus; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; zinc ion binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding; calcium-dependent protein kinase C activity;
Cellular component	cytoplasm; synaptic membrane; cytosol; cell projection; membrane; cell-cell junction; plasma membrane; synapse; intracellular anatomical structure; cell junction; dendrite; perinuclear region of cytoplasm; neuron projection; nucleus; postsynaptic density; calyx of Held; presynaptic cytosol; postsynaptic cytosol;
Biological process	negative regulation of neuron apoptotic process; intracellular signal transduction; phosphorylation; negative regulation of protein catabolic process; rhythmic process; regulation of response to food; platelet activation; chemosensory behavior; negative regulation of protein ubiquitination; protein phosphorylation; response to morphine; positive regulation of mismatch repair; response to pain; regulation of circadian rhythm; peptidyl-serine phosphorylation; learning or memory; protein autophosphorylation; negative regulation of proteasomal protein catabolic process; regulation of phagocytosis; innervation; chemical synaptic transmission; response to psychosocial stress; presynaptic modulation of chemical synaptic transmission; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5582
	18752
	ENSG00000126583
	ENSMUSG00000078816
	P05129
	P63318
	NM_002739; NM_001316329
	NM_001291434; NM_011102
	NP_001303258; NP_002730
	NP_001278363; NP_035232
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.^[5]^[6]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).^[7]

Interactions

PRKCG has been shown to interact with GRIA4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126583 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
^ Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. Bibcode:1986Sci...233..859C. doi:10.1126/science.3755548. PMID 3755548.
^ "Entrez Gene: PRKCG protein kinase C, gamma".
^ Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. 278 (8). United States: 6307–13. doi:10.1074/jbc.M205587200. hdl:10316/12633. ISSN 0021-9258. PMID 12471040.

External links

GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126583 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078816 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8432525-5] Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.

[pmid3755548-6] Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. Bibcode:1986Sci...233..859C. doi:10.1126/science.3755548. PMID 3755548.

[7] "Entrez Gene: PRKCG protein kinase C, gamma".

[pmid12471040-8] Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. 278 (8). United States: 6307–13. doi:10.1074/jbc.M205587200. hdl:10316/12633. ISSN 0021-9258. PMID 12471040.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PRKCG

Interactions

See also

References

Further reading

External links