Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Identifiers
EC no.	3.1.3.67
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myoinositol 4,5-bisphosphate + phosphate

This enzyme class belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1-phosphatidyl-D-myoinositol-3,4,5-trisphosphate 3-phosphohydrolase. Other names in common use include PTEN, MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. PTEN also refers to a member of the class, phosphatase and tensin homolog. This enzyme participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung cancer. It employs one cofactor, magnesium.

References

• Kabuyama Y, Nakatsu N, Homma Y, Fukui Y (1996). "Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus". Eur. J. Biochem. 238 (2): 350–6. doi:10.1111/j.1432-1033.1996.0350z.x. PMID 8681945.
• Maehama T, Dixon JE (1998). "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate". J. Biol. Chem. 273 (22): 13375–8. doi:10.1074/jbc.273.22.13375. PMID 9593664.

v t e Hydrolase: esterases (EC 3.1)
3.1.1: Carboxylic ester hydrolases	Cholinesterase Acetylcholinesterase Butyrylcholinesterase Pectinesterase 6-phosphogluconolactonase PAF acetylhydrolase Lipase Bile salt-dependent Gastric/Lingual Pancreatic Lysosomal Hormone-sensitive Endothelial Hepatic Lipoprotein Monoacylglycerol Diacylglycerol Phospholipase A1 A2 B Cutinase PETase
3.1.2: Thioesterase	Palmitoyl protein thioesterase Ubiquitin carboxy-terminal hydrolase L1 4-hydroxybenzoyl-CoA thioesterase
3.1.3: Phosphatase	Alkaline phosphatase ALPI ALPL ALPP Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases Nucleotidase Glucose 6-phosphatase Fructose 1,6-bisphosphatase Calcineurin Protein phosphatase PP2A OCRL Pyruvate dehydrogenase phosphatase Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase PTEN Phytase Beta-propeller phytase Inositol-phosphate phosphatase IMPA1, IMPA2, IMPA3 Protein phosphatase: Protein tyrosine phosphatase Protein serine/threonine phosphatase Dual-specificity phosphatase
3.1.4: Phosphodiesterase	Autotaxin Phospholipase C D Sphingomyelin phosphodiesterase 1 PDE1 PDE2 PDE3 PDE4A/PDE4B PDE5 Lecithinase (Clostridium perfringens alpha toxin) Cyclic nucleotide phosphodiesterase
3.1.6: Sulfatase	arylsulfatase Arylsulfatase A Arylsulfatase B Arylsulfatase L Steroid sulfatase Galactosamine-6 sulfatase Iduronate-2-sulfatase N-acetylglucosamine-6-sulfatase
Nuclease (includes deoxyribonuclease and ribonuclease)	3.1.11-16: Exonuclease Exodeoxyribonuclease RecBCD Exoribonuclease Oligonucleotidase 3.1.21-31: Endonuclease Endodeoxyribonuclease Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme;see {{Restriction enzyme}} UvrABC endonuclease Endoribonuclease RNase III Drosha: Microprocessor complex Dicer: RNA-induced silencing complex RNase H 1 2A 2B 2C RNase P RNase A RNase Z RNase E 1 2 3 4/5 RNase T1 either deoxy- or ribo-     Nuclease S1 Mung bean nuclease Serratia marcescens nuclease Micrococcal nuclease

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

This EC 3.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.

• v
• t
• e