CCL15
In this article we are going to delve into CCL15, a topic that has captured the attention of many people in recent times. In order to provide a comprehensive view of this issue, we will explore various aspects related to CCL15, from its origin to its current implications. Through a journey in which we will analyze its different facets, we intend to offer a detailed look that allows our readers to understand in a broad and complete way the relevance and impact that CCL15 has in modern society. By presenting data, expert opinions and testimonials, we seek to provide an enriching vision that invites reflection and debate about CCL15.
| chemokine (C-C motif) ligand 15 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCL15 | ||||||
| Alt. symbols | SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B | ||||||
| NCBI gene | 6359 | ||||||
| HGNC | 10613 | ||||||
| OMIM | 601393 | ||||||
| PDB | 2HCC | ||||||
| RefSeq | NM_032965 | ||||||
| UniProt | Q16663 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung.[1] It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3.[2][3] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.[4]
References
- ^ Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
- ^ Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
- ^ Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
- ^ Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.
External links
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